The Horse

MAR 2019

The Horse:Your Guide To Equine Health Care provides monthly equine health care information to horse owners, breeders, veterinarians, barn/farm managers, trainer/riding instructors, and others involved in the hands-on care of the horse.

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A35 TheHorse.com/AAEP2018 The Horse | AAEP Wrap-Up March 2019 YOUR GUIDE TO THE 2018 AAEP CONVENTION and a blend of amino acids including leucine. On Day 0 (before supplementa- tion), they collected baseline bloodwork and conducted an OST. The vet compared blood glucose and insulin concentrations in samples taken before syrup adminis- tration and then 60 and 75 minutes later. After 43 days of supplementation, they repeated the bloodwork and OST. The team also evaluated the supple- ment's effect on high-molecular-weight (HMW) adiponectin, a hormone found in fat tissue, because researchers have learned that horses with high levels of this hormone are more sensitive to insulin (a good thing). Researchers have shown that concentrations of this hormone are lower in ponies that develop laminitis than in those that don't, so raising HMW adiponectin levels could potentially decrease laminitis risk. The researchers said they had no trouble getting the horses to eat the supplement. They found no significant differences between the low- and high- dose groups after supplementation—all horses had significantly higher baseline HMW adiponectin concentrations and lower insulin concentrations 60 and 75 minutes after glucose administration. Researchers know equine insulin sen- sitivity decreases with age, which results in greater insulin level increases after an OST. Manfredi had insulin data on the same group of horses from a 2013 project, so she compared those figures to the ones from the current study. As expected, hors- es' mean baseline and 60-minute-post- OST insulin levels before supplementation in the current study were higher than they had been in 2013. However, she said, the average baseline insulin and 60-minute- post-OST results after six weeks of supplementation had decreased so much that they were not significantly different from what they'd been in 2013—a finding of particular interest, she said. These results led the team to conclude that feeding a supplemental mix of syner- gistic polyphenols and amino acids could help improve metabolic function in some horses with EMS and/or ID. h ONLINE extras Visit TheHorse.com/AAEP2018 ■ Managing and Monitoring Senior Horses With PPID, TheHorse.com/166357 ■ PPID and Laminitis in Horses: What's the Rela- tionship? TheHorse.com/166360 Feeding a supplement made up of synergistic polyphenols and amino acids could help improve metabolic function in some horses with EMS and insulin dysregulation. Managing horses with metabolic syndrome? InsulinWise (Patent Pending) TM Research-proven 60 75 40 45 50 55 60 65 70 75 80 85 90 Insulin concentraƟon (µIU/mL) in blood Minutes P<0.05 * P<0.05 * AŌer InsulinWise TM Before InsulinWise TM Insulin Concentrations Following OST Challenge Supplementation with InsulinWise significantly reduces insulin blood levels, signifying increased insulin sensitivity. • Maintains lower insulin levels, a marker of decreased insulin resistance • Reduces body weight • Supports increasing levels of adiponectin, an indicator of increased insulin sensitivity • Sustains a decreased risk of laminitis Available only through your veterinarian. Developed by: KPPvet.com, 859-873-2974 TH 2019-03 AAEP Ask your vet about

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